Formulation and Evaluation of Sustained Release Microspheres of Acetazolamide by Solvent Evaporation Technique

ISSN:0975-1459 Sustained release microcapsules of acetazolamide, a short half life carbonic anhydrase inhibitor, was developed to reduce the frequency of drug administration, ease of dose adjustment and improve patient compliance. In this study, sustained release microcapsules of acetazolamide was prepared by solvent evaporation techniques using Eudragit RL/RS as polymer and particle size, encapsulation efficiencies and in vitro release of the fabricated microcapsules were evaluated. The results showed that the encapsulation efficiencies were desired for all the formulations of microcapsules developed. Particle sizes of the microcapsules were influenced by the concentration of Eudragit and stirring speed. From the results of the in vitro study shows that the desired release rate is achieved by the combination of Eudragit RL and Eudragit RS.